Bone Marrow Changes in Adjuvant-Induced and Collagen-Induced Arthritis
نویسندگان
چکیده
منابع مشابه
Synergy between adjuvant arthritis and collagen-induced arthritis in rats
Adjuvant arthritis (AA) in rats is susceptible to cell-mediated passive transfer. Collagen-induced arthritis (CIA) in rats is susceptible to passive transfer with antibody to type II collagen. We report here the development of strikingly severe arthritis in Lewis rats as the result of synergy between passively transferred antibody to type II collagen from rats with CIA and concanavalin A (Con A...
متن کاملCollagen metabolism in adjuvant-induced arthritis in the rat.
The adjuvant arthritis of the rat is a systemic disease afflicting the musculoskeletal structures, accompanied by a number of visceral manifestations (Pearson, 1956; Pearson and Wood, 1959). It has been receiving considerable attention in studies of the factors that may influence the development and course of the rheumatic diseases in man (Leader, Gorham, and Wagner, 1967). This experimental ar...
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Total body irradiation followed by bone marrow transplantation was found to be an effective treatment for adjuvant arthritis induced in rats. This treatment is most effective when applied shortly after the clinical manifestation of arthritis--i.e., 4-7 weeks after administration of Mycobacterium tuberculosis. Transplantation of bone marrow at a later stage results in a limited recovery, in that...
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OBJECTIVE Mesenchymal stem cells (MSCs) are precursors of tissue of mesenchymal origin, but they also have the capacity to regulate the immune response by suppressing T and B lymphocyte proliferation in a non-major histocompatibility complex-restricted manner. Use of MSCs as immunosuppressant agents in autoimmune diseases has been proposed and successfully tested in animal models. We explored t...
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INTRODUCTION Postmenopausal women with rheumatoid arthritis (RA) have increased risk of developing osteoporosis due to chronic inflammation and estrogen deprivation. Collagen antibody-induced arthritis (CAIA), an experimental polyarthritis model representing the effector phase of arthritis, is mainly mediated by the innate immune system. Compared to the widely used collagen-induced arthritis mo...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1992
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780350219